About the Cover

COVER Illustration of projection neurons from the human cerebral cortex, with nuclei colored to reflect distinct sets of somatic DNA mutations. When a mutation occurs in a dividing cell, it marks all of the cell’s descendants. Identification of clones marked by mutation enables reconstruction of human brain development. Because developmental defects lie at the heart of many neurological diseases, understanding development is a primary goal of neuroscience. See pages 37 and 94.Illustration: C. Bickel/Science

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