Autophagy-mediated longevity is modulated by lipoprotein biogenesis.

Go to Publication » Autophagy-mediated longevity is modulated by lipoprotein biogenesis. Autophagy. 2016;12(2):261-72 Authors: Seah NE, de Magalhaes Filho CD, Petrashen AP, Henderson HR, Laguer J, Gonzalez J, Dillin A, Hansen M, Lapierre LR AbstractAutophagy-dependent longevity models in C. elegans display altered lipid storage profiles, but the contribution of lipid distribution to life-span extension is not fully understood. Here we report that lipoprotein production, autophagy and lysosomal lipolysis are linked to modulate life span in a conserved fashion. We find that overexpression of the yolk lipoprotein VIT/vitellogenin reduces the life span of long-lived animals by impairing the induction of autophagy-related and lysosomal genes necessary for longevity. Accordingly, reducing vitellogenesis increases life span via induction of autophagy and lysosomal lipolysis. Life-span extension due to reduced vitellogenesis or enhanced lysosomal lipolysis requires…


Link to Full Article: Autophagy-mediated longevity is modulated by lipoprotein biogenesis.

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