Dr Youguo Niu

Research Interests Fetal hypoxia and developmental programming of heart disease. The interaction between genetic make-up and environmental risk factors, such as smoking and obesity, promote a risk of heart disease. In addition, the concept of developmental programming has now become established. This states that a component of heart health and disease can be programmed before birth by the quality of the prenatal environment. The most common feature of complicated pregnancy, such as during preeclampsia or placental insufficiency, is fetal hypoxia. Over last 7 years, working under the supervision from Prof. Giussani, I have shown, in a variety of species, including chicken, rat, and sheep, that prental hypoxia programmes caridiac dysfunction at both fetal and adulthood stage, and this programming process is secondary to oxidative stress. Therefore, I have been testing…

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