From obesity resistance to obesity prediction and prevention?

1Dept. of Clinical and Experimental Medicine, University of Foggia, Italy 2Dept. of Physiology and Pharmacology “Vittorio Erspamer”, Sapienza University of Rome, Italy Eating disorders and obesity are urgent public health problem with a high burden of diseases for our societies. Core symptoms are unhealthy eating habits, with disturbances of eating behavior, and inability to control body weight.Food intake and energy balance are controlled as a complex, redundant, regulatory system ensuring that the amount of ingested calories does not exceed what the body can safely handle and that sufficient body fuel is stored as fat. The main brain regions integrating peripheral and central signals of this system are the hypothalamus and the brainstem. Key hypothalamic neurons are those co-expressing neuropeptide Y (NPY) and agouti-related protein (AgRP), which stimulate eating, and those…

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