Neuroscience Trials of the Future: A Workshop

MeetingWhile major strides have been made over the past two decades in basic neurosciences, the pace of translation into more effective treatments has eluded the field. Among the many factors contributing to this reality are the standard clinical trial methods that have barely changed, perhaps with the exception of increased use of electronic data acquisition and analysis. Clinical trials in neuropsychiatric disorders continue to suffer from high failure rates even with biological targets that are well validated. Even in the hands of experienced investigators, the now commonplace problem of poor assay sensitivity, and attendant trial failure, have adversely affected pharmaceutical and device development. Signal detection in CNS trials is regularly beset by high placebo or non-specific response, intra-subject variability of endpoints, inter-subject and inter-site variability in multicenter trials, poor treatment…

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