RNA-protein binding motifs mining with a new hybrid deep learning based cross-domain …

Abstract RNA plays important roles in cells through the interactions with proteins known as the RNA-binding proteins (RBP) and their binding motifs can provide crucial understanding of the post-transcriptional regulation of RNAs. How the RBPs correctly recognize the target RNA and why they bind specific positions is still far from clear. Artificial intelligence-based computational algorithms are widely acknowledged to be capable of speeding up this process. Although many automatic tools have been developed to predict the RNA-protein binding sites from the rapidly growing multi-resource data, e.g. from sequence, structure data etc, their different domain specific features and formats have posed significant computational challenges. One of current most difficulties is the cross-source shared common knowledge is usually at a higher abstraction level beyond the observed data, resulting in a low efficiency…


Link to Full Article: RNA-protein binding motifs mining with a new hybrid deep learning based cross-domain …

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