The hypothalamic QRFP: a neuropeptide between food and mood

The hypothalamus is a brain region implicated in several vital functions such as feeding, thermoregulation, reproduction, stress and metabolic regulation. Dozens of hypothalamic neuropeptides have been shown to be involved in the regulation of food intake and body weight homeostasis. The extreme heterogeneity of these chemical signals and the complex sub-architecture of the hypothalamus participate in regulating homeostatic adaptations.Information about the body’s energy store is gathered by the arcuate nucleus (Arc), a small hypothalamic nucleus, and then transmitted to second order neurons, including ones localized in the paraventricular nucleus (PVN) and others in the lateral hypothalamic area (LHA), to evoke hunger sensation and feeding behavior. Since the seminal study of Anand and Brubeck (1951), the LHA has been identified as the “feeding center of the brain”. However, the exact contribution…

Link to Full Article: The hypothalamic QRFP: a neuropeptide between food and mood

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